Drug likeness: what do bioavailability and toxicity properties tell us about...
Druglikeness is a qualitative concept used in drug design for an estimate on how “druglike” a prospective compound is. Usually it is estimated from the molecular structure, often even before... Related...
View ArticleLD50 vs. MRDD: what’s death for a mice is good enough for a man
Prediction of toxic properties of small drug like molecules is a big challenge both from theoretical and practical points of view. Quantitatively people use different measures of toxicity such as......
View ArticleDo we need those nM-inhibitors?
It’s “well known” that we all need to find the stronger inhibitors against any specific therapeutic target as possible. The motivation is that the strongest inhibitors are most probably less... Related...
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